Longevity / mitochondrial
SS-31 (Elamipretide)
FDA-approvedElamipretide, Forzinity, MTP-131 · Cardiolipin-targeting tetrapeptide
Cardiolipin-targeting peptide that restores mitochondrial function.
What it is
A cell-permeable tetrapeptide that concentrates on the inner mitochondrial membrane; in 2025 it became the first cardiolipin-directed mitochondrial therapy FDA-approved (Forzinity) for Barth syndrome.
How it works
Binds cardiolipin to stabilize mitochondrial cristae, improving electron-transport efficiency and ATP while cutting reactive oxygen species.
Studied for
Barth syndrome (approved); investigational for mitochondrial myopathy, heart failure, dry AMD.
Regulatory status
FDA-approved only for Barth syndrome; other uses investigational; 'SS-31' from research vendors is unregulated.
Safety
Injection-site reactions common; otherwise well tolerated in trials; use outside the approved indication is unproven.
What the community reports about SS-31 (Elamipretide)
Aggregated from real community discussions across social platforms and forums. Anecdotal and self-reported — not causal, not medical advice.
The mitochondrial repair tool. SS-31 (Elamipretide) stabilizes cardiolipin in the inner mitochondrial membrane, restoring the function of damaged mitochondria — "damage control" for the cell's power plants. In the mitochondrial trio it's the repair step (SS-31), run before NAD+ (fuel) and MOTS-c (optimize).
- Strong acute 'feel amazing' first dose — energy/euphoria that tapers
- Energy, oxidative-stress and body-comp gains; a community favorite
Aggregated from public discussions and community forums, synthesized into themes and counts. Anecdotal and self-reported — not causal, not evidence a compound is safe or effective, not medical advice, and not a recommendation to use. No dosing shown.
Educational information only — not medical advice, and not a recommendation to use any compound. Many peptides here are not approved for human use; legal status and evidence quality vary and are noted above. This page contains no dosing information. Consult a qualified clinician before making any health decision.