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Cognitive / neuro

Semax

Approved abroad

ACTH(4-10) analog · Nootropic neuropeptide

Russian nootropic peptide that raises BDNF and neuroplasticity.

Half-life
Minutes in plasma (CNS effects longer)
Route
Intranasal
Evidence
Approved in Russia for stroke/cognition; Western validation lacking.

What it is

A synthetic heptapeptide derived from an ACTH fragment but stripped of hormonal activity, developed in Russia for cognition and neuroprotection.

How it works

Upregulates BDNF/TrkB signaling and modulates dopamine/serotonin with antioxidant effects.

Studied for

Cognitive enhancement, stroke recovery, attention/memory, neuroprotection.

Regulatory status

Not FDA-approved; registered drug in Russia.

Safety

Generally well tolerated; possible nasal irritation; long-term Western safety data limited.

From the PeptideLab community · real discussions
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What the community reports about Semax

Aggregated from real community discussions across social platforms and forums. Anecdotal and self-reported — not causal, not medical advice.

Semax is a synthetic ACTH(4-7) analog developed in Russia and used as a non-stimulant nootropic that drives BDNF and dopaminergic signaling for focus, memory, mood, and post-injury cognitive recovery — most often delivered intranasally and almost always paired with Selank.

494
discussions analyzed
Multi-source
social + forums
Cognition / focus
most-discussed topic
What people discuss
Cognition / focus10.9%
Mood / anxiety10.7%
Recovery / healing10.5%
Energy / fatigue7.3%
Pain / joints6.3%
Most commonly stacked with
Selank 442 co-mentionsMOTS-c 160 co-mentionsBPC-157 156 co-mentionsGHK-Cu 114 co-mentions
Reported benefits
Coming soonBeta
Full breakdown coming to PeptideLab Pro
Typical reported dose ranges, cycle structures, warnings, and the complete community insight set — rolling out in the Pro app.

Aggregated from public discussions and community forums, synthesized into themes and counts. Anecdotal and self-reported — not causal, not evidence a compound is safe or effective, not medical advice, and not a recommendation to use. No dosing shown.

Reconstitution calculator →

Educational information only — not medical advice, and not a recommendation to use any compound. Many peptides here are not approved for human use; legal status and evidence quality vary and are noted above. This page contains no dosing information. Consult a qualified clinician before making any health decision.