GLP-1 / metabolic

Pramlintide

FDA-approved

Symlin · Amylin analog

Mealtime amylin analog adjunct to insulin.

Half-life

~48 minutes (with meals)

Route

Subcutaneous with meals

Evidence

FDA-approved — adjunct to mealtime insulin in type 1 and type 2 diabetes.

What it is

A synthetic analog of the beta-cell hormone amylin, used at meals alongside insulin; the only FDA-approved amylin analog.

How it works

Amylin-receptor agonism slows gastric emptying, suppresses postprandial glucagon and promotes satiety.

Studied for

Postprandial glucose control adjunct to insulin; modest weight effects.

Regulatory status

FDA-approved drug.

Safety

Boxed warning for severe insulin-induced hypoglycemia; nausea common; requires clinician-managed insulin adjustment.

Reconstitution calculator →

Educational information only — not medical advice, and not a recommendation to use any compound. Many peptides here are not approved for human use; legal status and evidence quality vary and are noted above. This page contains no dosing information. Consult a qualified clinician before making any health decision.