Cosmetic / skin
Matrixyl
Cosmetic (topical)Palmitoyl Pentapeptide-4 · Cosmetic signal peptide
Topical peptide that signals skin to build collagen.
What it is
A collagen-fragment pentapeptide (KTTKS) conjugated to palmitic acid for penetration, used in anti-aging cosmetics for firmness and wrinkles.
How it works
Acts as a matrikine signal, stimulating fibroblasts to make collagen, elastin and extracellular matrix.
Studied for
Wrinkle depth, firmness/elasticity, dermal thickness.
Regulatory status
Cosmetic ingredient (not a drug); OTC skincare.
Safety
Very well tolerated; low irritation potential.
Educational information only — not medical advice, and not a recommendation to use any compound. Many peptides here are not approved for human use; legal status and evidence quality vary and are noted above. This page contains no dosing information. Consult a qualified clinician before making any health decision.