Longevity / mitochondrial
Humanin
Preclinical (animal)Humanin (HNG analog) · Mitochondrial-derived peptide
Mitochondria-encoded cytoprotective, anti-apoptotic peptide.
What it is
A 24-amino-acid peptide encoded in mitochondrial DNA, first identified for protecting neurons from Alzheimer's toxicity; circulating levels fall with age.
How it works
Cytoprotective, anti-apoptotic signaling (via gp130-family receptors and IGFBP-3), improving metabolic and stress resistance.
Studied for
Neuroprotection/Alzheimer's, cardiometabolic protection, insulin sensitivity, aging.
Regulatory status
Not approved; research chemical.
Safety
Human safety data essentially absent; experimental only.
What the community reports about Humanin
Aggregated from real community discussions across social platforms and forums. Anecdotal and self-reported — not causal, not medical advice.
Aggregated from public discussions and community forums, synthesized into themes and counts. Anecdotal and self-reported — not causal, not evidence a compound is safe or effective, not medical advice, and not a recommendation to use. No dosing shown.
Educational information only — not medical advice, and not a recommendation to use any compound. Many peptides here are not approved for human use; legal status and evidence quality vary and are noted above. This page contains no dosing information. Consult a qualified clinician before making any health decision.