Longevity / mitochondrial
FOXO4-DRI
Preclinical (animal)D-retro-inverso FOXO4 peptide · Senolytic peptide
Experimental senolytic that clears senescent 'zombie' cells.
What it is
A D-amino-acid retro-inverso peptide designed to disrupt the FOXO4-p53 interaction inside senescent cells, investigated for clearing them.
How it works
Blocks FOXO4 from sequestering p53 in senescent cells, freeing p53 to trigger their selective apoptosis.
Studied for
Cellular senescence/aging, tissue regeneration, frailty (models).
Regulatory status
Not approved; research chemical.
Safety
No human safety data; systemic p53-mediated apoptosis carries theoretical risks; experimental only.
Educational information only — not medical advice, and not a recommendation to use any compound. Many peptides here are not approved for human use; legal status and evidence quality vary and are noted above. This page contains no dosing information. Consult a qualified clinician before making any health decision.